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KMID : 0363220170550090597
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Korean Journal of Dermatology
2017 Volume.55 No. 9 p.597 ~ p.601
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A Case of Combination Treatment with Oral Acitretin and Topical 5% Imiquimod Cream in an Immunosuppressive Patient with Widespread Verruca Plana
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Lim Jae-Yun
Kim Han-Saem
Kim Jung-In
Min Joon-Hong
Choi Young-Jun
Nam Jae-Hui
Chae Seoung-Wan
Lee Ga-Young
Kim Won-Serk
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Abstract
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Verruca plana is a subtype of warts, which are one of the most common dermatological diseases. A 37-year-old man presented with multiple asymptomatic skin-colored, 1∼2-mm, flat-topped papules on both arms, neck, and face. The patient had ulcerative colitis, which had been treated with immunosuppressants for 15 years. After skin biopsy, verruca plana was confirmed. The patient was treated with 5% imiquimod cream for 6 months. However, only mild improvement was observed. Acitretin was then added to the treatment regimen. After 44 weeks of treatment, acitretin was stopped. Dramatic and rapid clinical improvement was achieved after 3 weeks of treatment, and no sign of recurrence after treatment cessation has been reported for 60 weeks. Consequently, the combination of oral acitretin and topical 5% imiquimod cream should be recommended for the effective and safe treatment of recalcitrant verruca plana in immunosuppressed patients.
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KEYWORD
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Acitretin, Ulcerative colitis, Verruca plana
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